HLA-Cw6 Products - Molecular genetics

Information

HLA-C*06 alleles are the genetic component for the predisposition to the autoimmune reactions that result in psoriasis. Recent total-genome association studies have confirmed that of all gene sites HLA-C shows the highest association with psoriasis, and HLA-C*06 can be considered by far the most powerful genetic marker for the disease. The determination of HLA-C*06 is of great significance since the presence of the HLA-Cw6 antigen is associated in particular with type 1 psoriasis vulgaris (OR 16.0) and psoriasis guttata (OR 33.6), but only is comparatively weakly associated (OR 2.6) with type 2 psoriasis vulgaris. Type 1 psoriasis vulgaris has a more severe course than type 2 psoriasis vulgaris.

Diagnostic Guidelines

The EUROArray HLA-Cw6 Direct has been specifically designed for the determination of HLA-C*06 alleles. It is therefore particularly easy to perform compared to other molecular biological methods for the detection of HLA-C*06. In this test system the PCR primers have been chosen and optimized so that all relevant HLA-C*06 subtypes are detected.

HLA-Cw6 Direct products

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

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