HLA-DQ2/DQ8 Products - Molecular genetics

Information

Celiac disease is an autoimmune disease which occurs as a reaction to gluten sensitivity. The detection of the heterodimeric surface receptors HLA-DQ2 (HLA-DQ2.2 and -DQ2.5) and HLA-DQ8 may be related to the celiac disease.

The detection of the heterodimeric surface receptors HLA-DQ2 (HLA-DQ2.2 and -DQ2.5) and HLA-DQ8 may have significance in celiac disease (gluten-sensitive enteropathy), an autoimmune disease which occurs as a reaction to gluten sensitivity.

Diagnostic Guidelines

The EUROArray HLA-DQ2/DQ8 Direct was especially adjusted for the reliable determination of the disease-associated alleles HLA-DQA1- and HLA-DQB1, which code for the subunits HLA-DQ2.2, -DQ2.5 and -DQ8. The test system EUROArray HLA-DQ2/DQ8-h Direct provides a more comprehensive determination of the homo- and heterozygous presence of the alleles coding for HLA-DQ2.2 and -DQ2.5 respectively. Both analyses are extremely easy to perform. With the unique direct procedure, nucleic acid no longer needs to be isolated. The blood sample is treated with two extraction reagents and can then be used directly in the PCR. PCR primers and microarray probes are selected and optimized in such way that all relevant HLA-DQA1 and HLA-DQB1 alleles are clearly identified. Data analysis, data interpretation and electronic archiving are performed fully automated using the EUROArrayScan software. The accurate analysis of the alpha and beta subunits of the DQ2 and DQ8 molecules ensures reliable and unambiguous results.

HLA-DQ2/DQ8 Direct products

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

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